If all goes well, UFC heavyweight champion Junior Dos Santos (15-1 MMA, 9-0 UFC) will defend his title against Cain Velasquez (10-1 MMA, 8-1 UFC) in Toronto.
Following Friday's UFC on FX 3 post-event press conference, UFC president Dana White said the company's current plans call for Dos Santos vs. Velasquez II to serve as the headlining matchup of UFC 152.
The event takes place Sept. 22 at Air Canada Centre. Earlier Friday night, White also revealed Rory MacDonald vs. B.J. Penn will likely take place at UFC 152.
Dos Santos recently downed Frank Mir in the main event of May's UFC 146 event after defending an early takedown and then outboxing Mir before scoring a second-round TKO win en route to the first successful defense of his title.
The victory served as Dos Santos' 10th straight win overall, and he remains undefeated in the UFC octagon.
Meanwhile, Velasquez also competed at UFC 146, where he earned his first win since surrendering the belt to Dos Santos at this past November's UFC on FOX 1 event.
Facing Strikeforce import Antonio Silva, Velasquez was in vintage form and took the fight to the floor in the early going and pounding away from top position. A short Velasquez elbow opened a gash on Silva's head that bled profusely and left "Bigfoot" struggling to see. Velasquez was unrelenting with his ground-and-pound attack and earned a stoppage with his brutal assault at the 3:36 mark of the round.
With the win, Velasquez rebounded from the first professional loss of his career.
White first confirmed the rematch at the UFC 146 post-event press conference. However, at that time a targeted date was not revealed.
Source: Junior Dos Santos vs. Cain Velasquez II targeted for UFC 152 headliner